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中文

Instruments

Solid State Research

Panalytical Empyrean XRPD

 

Applications:

(1) Routine crystal form of API and Formulation Samples

(2) Quantification of Crystalline or Amorphous Content

(3) Variable humidity and temperature capability to monitor phase transitions

(4) Transmission or reflectance mode to measure in-tact drug product

Bruker 500 MHz WB ssNMR

 

Applications:

(1) Routine crystal form of API and Formulation Samples

(2) All relevant NMR nuclei accessible

(3) In-depth analysis of API/excipient interactions

(4) Amorphous dispersion physical stability

(5) Positive identification of salt or co-crystal formation

CM Protégé PharmD System

 

Applications:

(1) High throughput polymorph, salt and co-crystal screens

(2) High throughput solubility assays

TGA-Q500, Q5000

 

Applications:

(1) Determine hydrate or solvate formation of API

(2) Identify loose vs. bound solvent

(3) Optimize hydrate drying conditions

DSC-Q200, Q2000

 

Applications:

(1) Measure all thermal transitions for API

(2) Determine melting point and degradation range

(3) Understand polymorph stability

(4) Modulated capabilities for amorphous characterization

DXR Raman Microscope

 

Applications:

(1) Routine crystal form of API and Formulation Samples

(2) Quantification of Crystalline or Amorphous Content

(3) Ideal for drug product samples

Thermo Scientific Nicolet™ iS™10 (FT-IR)

 

Applications:

(1) A complete infrared spectroscopy system for routine analytical needs

(2) Delivering the highest confidence in the verification and identification of materials

Microtrac S-3500 PSD Analyzer (PSD)

 

Applications:

(1) Routine particle size measurement

(2) Solid or slurry feed

(3) Method development and validation

Malvern Mastersizer 3000E Particle Size Analyzer (PSD)

 

Applications:

(1) Routine particle size measurement

(2) Solid or slurry feed

(3) Method development and validation

SMS DVS Intrinsic DVS Intrinsic

 

Applications:

(1) Measure water uptake of API and formulation samples

(2) Determine critical water activity for hydrate conversion

(3) Identify hydrate formation at elevated humidity

Polarized Light Microscope ( AXIO LAB A1 Pol)

 

Applications:

(1) Morphology determination

(2) Determine crystalline character of analyte

(3) Extent of aggregation or agglomeration

Crystallization Technologies

Optimax

 

Applications:

(1) Crystallization development and optimization

(2) Automated reactions from 250-1000 ml

(3) Temperature control -40 to 180°C

(4) All events and data recorded automatically

(5) Combined use of in-line FBRM and ReactIR

Easymax

 

Applications:

(1) Crystallization development and optimization

(2) Automated reactions from 50-150ml

(3) Temperature control -40 to 180°C

(4) All events and data recorded automatically

(5) Combined use of in-situ FBRM and ReactIR

FBRM G400

 

Applications:

(1) in-situ cord length measurement

(2) Monitor nucleation and growth events

(3) Robust control of particle size

Crystal 16

 

Applications:

(1) Rapid solubility measurements with 16 parallel measurements

(2) MSZW calculations

ReactIR 45m

 

Applications:

(1) In-situ monitoring of reactions

Analytical Research

Agilent HPLC 1260, 1100 (6 units)

 

Applications:

(1) Routine crystal form of API and Formulation Samples

(2) Quantification of Crystalline or Amorphous Content

Agilent 7820A GC

Dionex ICS-1100

Agilent 708-DS Dissolution Dissolution (3 units)

 

Applications:

(1) Routine crystal form of API and Formulation Samples

(2) Quantification of Crystalline or Amorphous Content

Sirius T3 pKa

Metrohm 848 Titrino Plus

Metrohm 870 Karl Fisher Titrator

MEMMERT Temperature humidity chamber (HCP246)