Technical Articles
11 Apr 2025
Crystal’s Perspective: Polymorph Patent Landscape of 28 FDA-Approved Small Molecule Drugs in 2024
11 Apr 2025
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Crystal Pharmatech Solid State Characterization Service, which is referred to as Focused Analytical Solids Testing (FAST), covers many routine analyses encountered during pharmaceutical development. The FAST concept is directly aligned with our goal of partnering with organizations instead of merely providing data. Below table lists the sample amount and turnround time required for the different test items.
| Test Item | Sample Amount (mg) | Turnaround Time (working days) | Test Item | Sample Amount (mg) | Turnaround Time (working days) | |
X-ray power diffraction（XRPD） | 2-50 | 2 | HPLC (Assay) | 30-50 | 5 | |
| Particle Size Distribution (PSD) | 50-100 | 3-5 | CG Residual Solvents | 30-50 | 5 | |
| DSC (10℃/min) | 2-20 | 2 | pKa | 5-10 | 2 | |
| mDSC (3℃/min） | 2-20 | 2 | logP/D | 5-10 | 3 | |
| TGA (10℃/min) | 2-20 | 2 | Jet Milling | 1,000 (1 g) | 2 | |
| Polarized Light Microscopy (PLM) | 2-20 | 2 | BET | > 500 | 5 | |
| Dynamic Vapor Sorption (DVS) | 20-100 | 5 | LC-CAD | 10-20 | 5 | |
| KF | 100 | 2 | SCXRD | 50 | 5 | |
| Hot-Stage Microscopy | 2-20 | 2 | Dispersion Batch | 10,000 (10 g) | quote | |
| FTIR | 30-50 | 2 | MicroED | 10 | quote | |
| Solution NMR (1H) | 10 | 2 | qNMR for Purity | 10 | 7 | |
| ssNMR | 50-500 | 2 | qNMR with Linearity | 20 | 7 | |
| HPLC (Purity) | 10-20 | 2 | *Additional Processing | N/A | N/A |
